ChromoBlog

Why is the Fab-Trap™ so Fab-ulous?

Posted by Dr. Bennet Reiter on Nov 25, 2021 9:11:20 AM

Different antibody formats can be used in IP applications, including full-length antibodies, Fab-fragments, and Nanobodies. ChromoTek’s Fab-Trap™ is an IP reagent based on an antibody Fab-fragment. In this blog, we elaborate on the basic principle and advantages of Fab-fragment based reagents for IP. More simply, we ask “Why is the Fab-Trap™ Fab-ulous?”

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Topics: Nano-Traps, Immunoprecipitation, Fab-Trap

Advantages and limitations of different antibody formats in immunoprecipitation

Posted by Dr. Bennet Reiter on Nov 25, 2021 8:52:38 AM

Immunoprecipitation (IP) is a technique used to isolate a protein from a cellular extract. The protein of interest (POI) is recognized by a specific antibody (Ab) conjugated to beads. Different antibody formats can be used in IP, e.g., a full-length Ab, a Fab-fragment, or a Nanobody. Below, we discuss the advantages and limitations of the different Ab formats.

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Topics: Nano-Traps, Immunoprecipitation, Nanobody, Fab-Trap

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